Immediate Reversal of Hypoxemia With PFO Closure in Carcinoid Heart Disease and Platypnea-Orthodeoxia Syndrome

Q: What does this research mean for the field?

Percutaneous closure of a patent foramen ovale (PFO) leads to immediate and sustained reversal of hypoxemia in patients with carcinoid heart disease and platypnea-orthodeoxia syndrome. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jose F. Eduardo; José-Alejandro Ramírez-Penuela; Fabrício Malaguez Webber; Jesse Medina; Joao Braghiroli; Camilo Gomez

doi:10.1016/j.jaccas.2025.106659

March 1, 2026JACC Case ReportsOpen Access

Immediate Reversal of Hypoxemia With PFO Closure in Carcinoid Heart Disease and Platypnea-Orthodeoxia Syndrome

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Key Points

This research aims to evaluate the effectiveness of percutaneous closure of a patent foramen ovale (PFO) in treating persistent hypoxemia associated with carcinoid heart disease.
Identified cases of persistent hypoxemia with negative pulmonary assessments.
Performed timely percutaneous closure of PFOs on eligible patients.
Monitored patients' oxygen levels post-procedure for improvements.
Patients showed immediate reversal of hypoxemia after the PFO closure.
Improvements in oxygen saturation were sustained over time.
No significant complications noted from the procedure.

Implication

Observational study shows rapid improvement in hypoxemia after PFO closure in patients, suggesting effective intervention.

Abstract

Consider a PFO in persistent hypoxemia despite a negative pulmonary work-up. Timely percutaneous closure may lead to rapid, sustained improvement.

Discussion

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Cite This Study

Eduardo et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc0eb39f7826a300ca77 https://doi.org/10.1016/j.jaccas.2025.106659

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Immediate Reversal of Hypoxemia With PFO Closure in Carcinoid Heart Disease and Platypnea-Orthodeoxia Syndrome

Key Points

Implication

Abstract

Discussion

Cite This Study

Immediate Reversal of Hypoxemia With PFO Closure in Carcinoid Heart Disease and Platypnea-Orthodeoxia Syndrome

Key Points

Implication

Abstract

Discussion

Cite This Study

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