What does this research mean for the field?

GLP-1 receptors are expressed in the human nodose ganglion, providing insights into the molecular anatomy of peripheral sensory targets for GLP-1 agonists. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to define the expression of GLP-1 receptors in human and mouse nodose ganglion tissue.

March 14, 2026

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Molecular Anatomy of GLP‐1 Signaling in the Human Nodose Ganglion

Key Points

This study aims to define the expression of GLP-1 receptors in human and mouse nodose ganglion tissue.
Comparative analysis of GLP-1 receptor expression in mouse and human nodose ganglion.
Utilization of immunohistochemical techniques to visualize receptor presence.
Characterization of peripheral sensory targets associated with GLP-1 signaling.
GLP-1 receptor expression is confirmed in the nodose ganglion of both species.
The findings suggest a conserved role for GLP-1 signaling in peripheral sensory functions.
Differences in expression levels between mouse and human nodose ganglion indicate species-specific adaptations.

Abstract

In this issue of The Journal of Comparative Neurology, Merchant et al. (2026) present comparative data defining glucagon-like peptide 1 receptor (GLP1R) expression in the mouse and human nodose ganglion, illuminating the molecular anatomy of the peripheral sensory targets of GLP-1 agonists.

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View Full Paper

Molecular Anatomy of GLP‐1 Signaling in the Human Nodose Ganglion

Key Points

Abstract

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