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Comparative efficacy of pharmacologic therapies for MASLD in improving fibrosis: systematic review and network meta-analysis

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Systematic review and network meta-analysis finds pharmacologic therapies improve fibrosis in MASLD, indicating potential treatment options.

To compare the efficacy of pharmacologic therapies for MASLD in improving fibrosis using various assessments.
Conducted a systematic review of randomized controlled trials (RCTs) related to drug therapy for MASLD.
Included histopathological and noninvasive assessments to measure treatment efficacy.
Analyzed data using surface under the cumulative ranking curve (SUCRA) for treatment rankings.
Pegozafermin, obeticholic acid, and resmetirom showed significant efficacy in improving fibrosis compared to placebo.
OCA demonstrated superior outcomes in a 1.5-year follow-up compared to placebo.
Pegozafermin ranked highest in reducing liver stiffness measurement via VCTE in the 0.5-year analysis.

Han et al. (2026) studied this question.

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Systematic review and network meta-analysis finds pharmacologic therapies improve fibrosis in MASLD, indicating potential treatment options.