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March 15, 2026Dermatologica SinicaOpen Access

Randomized controlled trial to compare the efficacy of oral minoxidil 1.25 mg versus 2.5 mg versus topical 5% minoxidil in androgenetic alopecia

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Authors

BMBhumika MahawarMahatma Gandhi Mission Medical College and HospitalADAshish DeshmukhMahatma Gandhi Mission Medical College and Hospital

Discussion

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Implication

Randomized controlled trial compares oral minoxidil doses to topical 5% minoxidil, indicating similar treatment efficacy for hair regrowth.

Key Points

  • To compare the efficacy of different doses of oral minoxidil versus topical minoxidil in androgenetic alopecia.
  • Randomized controlled trial with 45 male AGA patients allocated to three groups
  • Group A: 1.25 mg oral minoxidil, Group B: 2.5 mg oral minoxidil, Group C: topical 5% minoxidil
  • Treatment duration of 6 months with evaluations of hair count, photographic assessments, and self-assessments.
  • Significant increase in terminal hair count in all groups after 6 months
  • No statistical difference in efficacy among oral and topical minoxidil groups
  • Patients in oral minoxidil groups reported higher satisfaction with hair appearance.

Cite This Study

Mahawar et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff3b83145bc643d1b5dahttps://doi.org/10.4103/ds.ds-d-25-00094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia2024 · 61 citations
  2. 2There Is a Positive Dose-Dependent Association between Low-Dose Oral Minoxidil and Its Efficacy for Androgenetic Alopecia: Findings from a Systematic Review with Meta-Regression Analyses2022 · 20 citations
  3. 3Clinical efficacy and safety of low‐dose oral minoxidil versus topical solution in the improvement of androgenetic alopecia: A randomized controlled trial2023 · 34 citations
  4. 4Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells1998 · 295 citations
  5. 5Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment2020 · 101 citations