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March 15, 2026Chemical Biology & Drug Design

Design and Synthesis of New Triazol Derivatives as Aromatase Enzyme Inhibitors

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Authors

AÇAbdullah ÇelikHBHayrani Eren BostancıSGSemih Görgülü

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Overview

Novel triazole derivatives show selective cytotoxicity in MCF-7 cells, suggesting potential aromatase inhibition in breast cancer.

Key Points

  • To design and synthesize new triazole derivatives as aromatase enzyme inhibitors for breast cancer treatment.
  • Designed and synthesized triazole derivatives through a two-step organic synthesis process.
  • Evaluated anticancer activities using the MTT assay in MCF-7 and L929 cell lines.
  • Conducted molecular docking studies to investigate interactions with the aromatase enzyme.
  • Assessed the pharmacokinetic properties through ADME profiles.
  • Some triazole derivatives exhibited selective cytotoxicity in MCF-7 and L929 cell lines.
  • The inhibitory effects were compared with letrozole, a known aromatase inhibitor.
  • Molecular docking revealed binding energies and specific amino acid interactions with the aromatase enzyme.

Cite This Study

Çelik et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8d83145bc643d1c481https://doi.org/10.1111/cbdd.70276
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design, Synthesis and Molecular Modeling Studies of Triazole Derivatives as Aromatase İnhibitors2026
  2. 2Synthesis, Characterization, and In vitro and In Silico Studies of New Triazole Derivatives as Aromatase Inhibitors2024 · 1 citations
  3. 3Discovery of potential 1,2,4-triazole derivatives as aromatase inhibitors for breast cancer: pharmacophore modelling, virtual screening, docking, ADMET and MD simulation2024 · 5 citations
  4. 4Synthesis and In Vitro Evaluation of Anticancer Activity of Fluorophenyl Derivatives of 1,3,4-Thiadiazole Against Estrogen-Dependent Breast Cancer2025 · 1 citations
  5. 5Synthesis, In vitro and In silico Studies of Novel bis‐triazolopyridopyrimidines from Curcumin Analogues as Potential Aromatase Agents2024 · 6 citations