PRx before mannitol and RMannitol causality suggests that compensatory cerebral vasoconstriction drives mannitol response. RMannitol and GOSE inverse relationship underscores the importance of ICP monitoring and timely treatment escalation. The PRx before mannitol, RMannitol, and GOSE causal relationship suggests that considering both RMannitol and PRx may improve patient outcomes. SCMMannitol may estimate heterogeneous treatment effects, advancing precision medicine for patients with traumatic brain injury.
Jung et al. (Fri,) studied this question.