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March 1, 2026European Journal of Pain

Patient‐Related Predictors of Opioid Use, Pain and Opioid‐Related Adverse Events in the First 24 h After Surgery: A Systematic Review and Meta‐Analysis

Caroline Risegaard Folkersen Ida Rasmussen Pernille Bjersand Sunde Selma Pedersen Kjartansdóttir A Saito Markus Harboe Olsen Jens Laigaard Mathias Maagaard Ole Mathiesen Anders Peder Højer Karlsen

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Key Points

To identify patient-related predictors of opioid use, pain, and adverse events following surgery.
Conducted a systematic review and meta-analysis
Analyzed data from multiple studies regarding opioid use and pain
Focused on predictors of opioid-related adverse events in the first 24 hours after surgery.
Identified significant predictors for opioid use and pain levels after surgical procedures
Highlighted relationships between patient characteristics and the likelihood of experiencing adverse events
Emphasized the importance of personalized postoperative care based on patient predictors.

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Implication

Systematic review shows links between patient-related factors, opioid use, and pain after surgery, indicating need for tailored care.

Abstract

Crd42024559821.

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Cite This Study

Folkersen et al. (2026) studied this question.

synapsesocial.com/papers/69b6069b83145bc643d1ca39 https://doi.org/10.1002/ejp.70242

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Impact of Opioid-Sparing Analgesia on Postoperative Pain and Recovery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2025 · 38 citations
2Association of pre‐operative opioid use disorder and postoperative outcomes: a systematic review and meta‐analysisSystematic Review · 2026
3Prevalence and Predictors of Persistent Post-Surgical Opioid Use: A Prospective Observational Cohort StudyCohort Study · 2017 · 130 citations
4Painfully Obvious? Non‐Operative Drivers of Post‐Operative Pain and Opioid Exposure in a Predominantly Emergency Surgical Cohort: A Multicentre Observational Study Identifying Non‐Operative, Perioperative Pain Correlates2025 · 2 citations
5Opioid versus opioid-free analgesia after surgical discharge: protocol for a systematic review and meta-analysisMeta-Analysis · 2020 · 11 citations

Persistent Postoperative Opioid Use: Progressing From Risk Identification to Risk Reduction2024
Increased health care costs associated with new persistent opioid use after major surgery in opioid-naive patients2021
Predicting Postoperative Pain: A Complex Interplay of Multiple Factors2021
Ecological Momentary Assessments of Daily Pain Experiences in Bothersome and High‐Impact Chronic PainEuropean Journal of Pain · 2026
Adverse Childhood Experiences ( ACEs ) in Patients With Persistent Pain Are Associated With Low Health‐Related Quality of Life and Distress—Perceived Injustice Mediates the Association Between ACEs and Pain InterferenceEuropean Journal of Pain · 2026

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