Late Venous Thromboembolism Chemoprophylaxis and Increased Risk of Deep Venous Thrombosis, Pulmonary Embolism, and Mortality in Patients with Traumatic Spinal Injury

Morgan F. Gaither; Karyssa M Nelson; Kayla Wilson; Sarah McWilliam Schmaltz; Joseph J. DuBose; Pedro G Teixeira; Tatiana Cárdenas; Sádia Ali; Michelle Robert; Carlos VR Brown

doi:10.1097/xcs.0000000000001917

March 13, 2026Journal of the American College of Surgeons

Late Venous Thromboembolism Chemoprophylaxis and Increased Risk of Deep Venous Thrombosis, Pulmonary Embolism, and Mortality in Patients with Traumatic Spinal Injury

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Key Points

To assess how timing of chemoprophylaxis affects venous thromboembolism and mortality in traumatic spinal injury patients.
National cohort study of patients with traumatic spinal injuries
Evaluated timing of chemoprophylaxis related to complications
Analyzed rates of venous thromboembolism, pulmonary embolism, and mortality
Late initiation of chemoprophylaxis ≥48 hours after admission is linked to increased venous thromboembolism
Association found with higher mortality rates
Findings advocate for early chemoprophylaxis initiation when possible

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Implication

Cohort analysis shows late chemoprophylaxis increases venous thromboembolism and mortality in spinal injury patients, suggesting urgent intervention is crucial.

Abstract

In this national cohort of traumatic spinal injuries, chemoprophylaxis initiated ≥48 hours after admission was independently associated with increased venous thromboembolism and mortality. These findings support early initiation when clinically feasible while highlighting the need for prospective evaluation of bleeding risk.

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Gaither et al. (2026) studied this question.

synapsesocial.com/papers/69b6069b83145bc643d1caaa https://doi.org/10.1097/xcs.0000000000001917

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Late Venous Thromboembolism Chemoprophylaxis and Increased Risk of Deep Venous Thrombosis, Pulmonary Embolism, and Mortality in Patients with Traumatic Spinal Injury

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Late Venous Thromboembolism Chemoprophylaxis and Increased Risk of Deep Venous Thrombosis, Pulmonary Embolism, and Mortality in Patients with Traumatic Spinal Injury

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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