Loss of SIRT1 reveals proteomic signatures of aging in testis, indicating a link to subfertility.
Our findings indicate that partial loss of SIRT1 is sufficient to trigger proteomic and functional hallmarks of testicular aging. In particular, we identified specific proteomic signatures linked to subfertility, including the loss of key capacitation-related proteins regulated by SIRT1 in the testis, a pattern also observed in aged animals, which may represent a mechanistic model of SIRT1-governed fertilization failure.
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Iniesta‐Cuerda et al. (2026) studied this question.
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