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January 1, 2026BLOOD CELL THERAPY / The official journal of APBMTOpen Access

Fecal Calprotectin as a biomarker for early diagnosis and prediction of steroid response in Acute Gastrointestinal Graft versus Host Disease

Santhosh E. Kumar Sushil Selvarajan Tintu Varghese P Krishna Bharadwaj Kovi Sai Lakshmi Shreyas Hanmantgad A K Dutta A J Joseph Vikram Mathews Biju George

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Key Points

To evaluate fecal calprotectin as a biomarker for diagnosing acute gastrointestinal graft versus host disease and predicting treatment response.
Measured fecal calprotectin on day 1 of diarrhea
Assessed diagnosis of acute GI-GVHD
Evaluated treatment response based on calprotectin levels
Higher fecal calprotectin values correlate with acute GI-GVHD diagnosis
Elevated calprotectin predicts poor treatment response

Implication

Demonstrates that fecal calprotectin values diagnose acute GI-GVHD and predict treatment outcomes, indicating its clinical usefulness.

Abstract

A higher FC value on day 1 of diarrhea aids in the diagnosis of acute GI-GVHD and predicts poor response to treatment.

Discussion

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Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69b64c33b42794e3e660d9d4 https://doi.org/10.31547/bct-2025-016

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Fecal calprotectin as a biomarker for the diagnosis of gastrointestinal graft-versus-host disease following allogeneic hematopoietic stem cell transplantationObservational Study · 2026
2The Diagnostic Accuracy of Fecal Calprotectin for Colonoscopic Abnormalities in Patients With Chronic DiarrheaCohort Study · 2026 · 2 citations
3Fecal Calprotectin in Nosocomial Diarrhea: A Prospective Observational Study2024
4Faecal Calprotectin: A Non-Invasive Marker for Diagnosing and Monitoring Acute DiverticulitisNarrative Review · 2026
5Low fecal calprotectin predicts clinical remission in Crohn's disease patients: the simple answer to a challenging questionRetrospective Study · 2019 · 10 citations

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