Mendelian randomization analysis finds that higher placental weight may lower risk of preeclampsia, suggesting important metabolic links.
These MR findings support a protective association of higher PW with PE/E risk and are consistent with a partial contribution of very large HDL lipid pathways. Given the assumptions of MR mediation and the possibility of overlapping metabolic pathways, these results should be interpreted as evidence consistent with mediation rather than definitive mechanistic proof.
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Li et al. (2026) studied this question.
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