Deep Brain Stimulation in the Middle East: First UAE Experience Comparing Subthalamic and Pallidal Targets for Parkinson’s disease

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Key Points

To compare outcomes of deep brain stimulation targeting the subthalamic nucleus and globus pallidus internus in patients with Parkinson's disease in the UAE.
Retrospective review of 50 patients undergoing bilateral DBS (37 STN, 13 GPi) from 2020 to 2025.
Collected data on demographics, clinical phenotype, LEDD, UPDRS-III scores, and adverse events.
Summarized outcomes by DBS target with exploratory comparisons.
GPi patients had earlier motor symptoms and universal dyskinesias; STN candidates had more heterogeneous phenotypes.
Both targets significantly reduced LEDD (STN 49.9%, GPi 37.5%).
Mean OFF-med to DBS-ON UPDRS-III improvement exceeded 80% for both targets.

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This analysis compares outcomes of STN and GPi deep brain stimulation in Parkinson’s disease, indicating potential effectiveness in the UAE.

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Mittal et al. (2026) studied this question.

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