Meta-analysis compares treatment persistence in alcohol use disorder between naltrexone formulations, suggesting formulation influences retention.
This meta-analysis suggests higher treatment persistence among patients with AUD receiving XR-NTX versus oral NTX, underscoring formulation as a key factor in persistence and retention. However, alcohol-related healthcare utilization metrics, including ED visits and hospitalizations, showed no significant between-group differences. Further pragmatic trials accounting for patient preferences, sex-specific outcomes, and barriers to care accessibility are needed.
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Núñez et al. (2026) studied this question.
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