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March 15, 2026Molecular & Cellular Proteomics0 citationsOpen Access

Urine proteomics as a source of biological information and outcome predictor in living kidney transplantation

KHK. Johanna R. Hoyer-AlloUniversity of ColognePAPatrick AffeldtUniversity Hospital CologneJLJan‐Wilm LackmannTH Köln - University of Applied Sciences

Key Points

  • This research aims to explore urine proteomics to identify biological markers that can predict outcomes in kidney transplantation.
  • Analyzed urine samples from kidney transplant recipients.
  • Identified proteins using proteomic techniques.
  • Assessed correlations with clinical outcomes, such as graft function and rejection episodes.
  • Specific protein markers correlated with kidney transplant success.
  • Urine proteomics helped predict the risk of antibody-mediated rejection.
  • Higher levels of certain proteins were associated with decreased estimated glomerular filtration rate.

Abstract

Abbreviations: albumin (ALB), alpha-1-microglobulin/bikunin precursor (AMBP), Alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1), Amyloid-beta precursor protein (APP), antibody-mediated rejection (ABMR), BK polyomavirus (BKVPyV), carbonic anhydrase (CA1), Chronic kidney disease (CKD), collagen domain containing adiponectin (ADIPOQ), Collagen Type XVIII Alpha 1 Chain (COL18A1), Cytomegalovirus (CMV), de novo DSA (dnDSA), Dermatopontin (DPT), end-stage renal disease (ESRD), endosomal sorting complexes required for transport (ESCRT), epidermal growth factor (EGF), Epstein-Barr virus (EBV), estimated glomerular filtration rate (eGFR), fatty acid binding protein 4 (FABP-4), Forkhead box O (FoxO), gene ontology (GO), Haptoglobin (HP), human prion protein gene (PRNP), hypoxiainducible factor-1 (Hif-1), Immunoglobulin Kappa Variable 3-20 (IGKV3-20), immunoglobulin lambda variable 2-11 (IGLV2-11), Interleukin 1 Receptor Accessory Protein (IL1RAP), Intracellular Cholesterol Transporter 2 (NPC2), keratin 1 (KRT1), keratin 9 (KRT9), Kidney transplantation (KTx), Kininogen-1 (KNG1), lymphatic vessel endothelial receptor 1 (LYVE1), nuclear factor kappa B (

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Cite This Study

Hoyer-Allo et al. (2026) studied this question.

synapsesocial.com/papers/69b64c9ab42794e3e660dca3https://doi.org/10.1016/j.mcpro.2026.101551
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