This analysis reveals how borderline resectable criteria affect treatment outcomes in hepatocellular carcinoma, indicating treatment effectiveness may mitigate poor prognostic factors.
Macrovascular invasion significantly impacted prognosis in patients undergoing hepatectomy, for both BR1 and BR2, whereas any of the tumor factors did not affect the prognosis of patients receiving systemic chemotherapy. Tumor burden correlated with prognosis in the entire cohort but not in chemotherapy responders, suggesting effective treatment may overcome poor prognostic indicators.
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Komatsu et al. (2026) studied this question.
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