Front cover highlights how different docking strand architectures influence imaging accuracy in nanoscale topography.
The Front Cover shows how DNA—PAINT docking strand architecture influences nanoscale image quality. Short single—motif docking strands keep localizations tightly clustered around trimeric PCNA, thus enabling precise molecular detail. In contrast, extended multivalent sequences expand the accessible volume, causing broader, less accurate patterns and reflecting the balance between imaging speed and structural accuracy. More information can be found in the Research Article by D. Helmerich, G. Beliu, and co-workers (DOI: 10.1002/cphc.202500803). Image created in BioRender: Helmerich, D. (2026) https://BioRender.com/3plpbtv.
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Helmerich et al. (2026) studied this question.
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