miR-23b-3p deficiency exacerbates immune dysregulation in immunoglobulin A vasculitis by enhancing TLR4-mediated dendritic cell activation

Key Points

• To explore the role of miR-23b-3p in regulating immune responses in immunoglobulin A vasculitis (IgAV).
• Investigated the effects of miR-23b-3p deficiency on dendritic cell (DC) maturation and function.
• Analyzed the TLR4-dependent pathway involved in Tfh differentiation.
• Assessed strategies for restoring miR-23b-3p expression to evaluate therapeutic potential.
• MiR-23b-3p deficiency worsened IgAV symptoms through increased DC-Tfh axis activation.
• Restoring miR-23b-3p expression led to reduced immune dysregulation.