What does this research mean for the field?

13-cis-retinoic acid treatment reduces the metastatic potential of KLN 205 murine squamous carcinoma cells by altering cell surface glycoconjugate expression. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to explore how 13-cis-retinoic acid affects cell surface changes and reduces the metastatic capabilities of tumor cells.

March 16, 2026JNCI Journal of the National Cancer Institute

Modulation of the Metastatic Phenotype by 13- cis -Retinoic Acid

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Authors

MCMarion CouchIndiana University School of Medicine BPBendicht U. PauliUniversity of Bern RWRonald S. WeinsteinUniversity of Arizona

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Implication

Demonstrates reduced metastatic potential in tumor cells treated with 13-cis-retinoic acid, indicating its role in cancer therapy.

Key Points

The aim is to explore how 13-cis-retinoic acid affects cell surface changes and reduces the metastatic capabilities of tumor cells.
KLN 205 murine squamous carcinoma cells grown in medium with varying concentrations of 13-cis-retinoic acid.
Flow cytometric analysis of cell surface glycoconjugate expression using fluoresceinated lectins.
Conducted a lung colony assay to assess the metastatic potential after treatment.
RA treatment altered glycoconjugate expression in a dose-dependent manner.
After 15 days, treated cells showed a significant decrease in lung colonization potential (P = .0003).
Enzymatic alteration mimicking RA treatment also reduced metastasis capability (P = .0022).

Cite This Study

Couch et al. (1987) studied this question.

synapsesocial.com/papers/69b79e538166e15b153ab732 https://doi.org/10.1093/jnci/78.5.971

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Modulation of the Metastatic Phenotype by 13- cis -Retinoic Acid

Discussion

Member takes

Implication

Key Points

Cite This Study

Modulation of the Metastatic Phenotype by 13- cis -Retinoic Acid

Discussion

Member takes

Implication

Key Points

Cite This Study

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