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March 16, 2026Nature CommunicationsOpen Access

Frazzled/DCC directs spatial progenitor integration ensuring steady-state intestinal turnover

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Authors

LZLisa ZipperPRP. Ramon-CañellasFAFiliz Akkas-Gazzoni

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Overview

This research demonstrates directed enteroblast migration to replace enterocytes, indicating a novel mechanism for intestinal homeostasis.

Key Points

  • The study aims to uncover the mechanism behind the replacement of intestinal epithelial cells by enteroblasts.
  • Developed the Hamelin assay to observe enteroblast migration.
  • Analyzed the interaction between worn-out enterocytes and enteroblasts.
  • Investigated the role of Netrin-B ligands in guiding enteroblast movement.
  • Examined the integration of progenitors in both the midgut and hindgut.
  • Frazzled/DCC signaling directs enteroblasts to migrate towards enterocytes expressing Netrin-B.
  • Enteroblasts replace both adjacent and remote enterocytes at identical frequencies.
  • Observations suggest invasive progenitor behavior as they cross the organ boundary.

Cite This Study

Zipper et al. (2026) studied this question.

synapsesocial.com/papers/69b79e7c8166e15b153abd03https://doi.org/10.1038/s41467-026-70704-9
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