Key result
Clozapine use linked to severe cardiopulmonary events including third-degree AV block and respiratory failure.
Clozapine use may be associated with severe cardiopulmonary adverse effects, including third-degree atrioventricular block and respiratory failure.
Warrants vigilant cardiopulmonary monitoring in clozapine-treated patients; leaves open incidence and causality pending controlled studies.
The atypical antipsychotic clozapine is highly effective for patients with treatment‐resistant schizophrenia. However, its well‐recognized side‐effect profile, including severe toxicity such as agranulocytosis, limits its use. Significant cardiopulmonary adverse effects also have been associated with clozapine.
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Y. W. Francis Lam (2026) studied this question. Clozapine usage can lead to serious cardiopulmonary adverse effects, including third-degree atrioventricular block and respiratory failure.
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