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This research aims to characterize a second-generation recombinant strain of HIV-1 CRF02_AG in Ningxia, China.

Near-full-length genomic characterization and phylogenetic analysis of an HIV-1 CRF02_AG/G second-generation recombinant in Ningxia, China

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Molecular characterization reveals a novel HIV-1 recombinant in Ningxia, highlighting the need for ongoing surveillance.

This research aims to characterize a second-generation recombinant strain of HIV-1 CRF02_AG in Ningxia, China.
Conducted genotyping screening of the pol region in HIV-1-infected individuals.
Obtained near-full-length genome sequence of the strain.
Performed phylogenetic analysis of gag, pol, and env gene regions.
Utilized jpHMM and Simplot software for recombination analysis.
Conducted Bayesian phylogeographic analysis to trace genetic relationships.
Identified a novel CRF02_AG/G recombinant strain in Ningxia.
Phylogenetic analysis indicated clustering with A1 and G subtypes.
Confirmed two G subtype fragments inserted into the env region.
Revealed close genetic relationships with CRF02_AG strains from the UK and South Korea.

Mutalifu et al. (2026) studied this question.

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