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March 17, 2026ACS Nano

Cellular Adaptive Component-Mediated Targeting of Chylomicron-Mimic Nanoemulsion to Hepatic Stellate Cells for Liver Fibrosis

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Authors

YHYilong HuYQY. QiJMJiapeng Mao

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Overview

Cell adaptive component-based strategy targets liver fibrosis, highlighting a novel antifibrotic approach.

Key Points

  • To investigate a targeted therapy strategy for liver fibrosis using a chylomicron-mimic nanoemulsion.
  • Developed a chylomicron-like lipid nanoemulsion for liver targeting.
  • Achieved cellular-level targeting via macrophage phagocytosis and HSC uptake.
  • Employed phosphatidylinositol for enhanced endocytic trafficking.
  • Combined nanoemulsion therapy with PPAR-γ agonists.
  • The nanoemulsion suppressed early fibrosis by reducing ERS in HSCs.
  • Combination treatment with PPAR-γ agonists reversed advanced fibrosis.
  • Targeting enabled organ and cellular-level drug delivery.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef12deb47d591b8c52f8https://doi.org/10.1021/acsnano.6c00741
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