PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 17, 2026Communications Medicine0 citationsOpen Access

Unbiased characterization of COVID-19 endotypes leads to prognostication of high-risk individuals using routine blood tests

WMWilliam MaASAntoine SouléCACatherine Allard

Key Points

  • To define COVID-19 endotypes and their implications for diagnosis and prognosis in patients.
  • Conducted unsupervised proteomic analysis
  • Identified biologically coherent endotypes
  • Analyzed the relationship between endotypes and acute lung injury
  • Identified distinct COVID-19 endotypes
  • Linked endotypes to improved diagnostic methods
  • Highlighted prognostic capabilities using routine blood tests

Abstract

Unsupervised proteomic analysis identified biologically coherent endotypes that advance understanding of acute lung injury in COVID‑19 and support improved diagnostic and prognostic strategies.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef6ddeb47d591b8c58adhttps://doi.org/10.1038/s43856-026-01520-x
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Classification of Patients With COVID‐19 Based on Transcriptional Profiling2026
  2. 2Prospective multicentre study of upper respiratory mucosal transcriptomics reveals two major endotypes of critically ill COVID-19 patients2026
  3. 3In-depth serum proteomics atlas of COVID-19 defines a Severity-Resistance Index from a four-protein panel for disease severity and prognosis2026
  4. 4Computational proteomics to enhance personalized treatment of COVID-19 and Long COVID2026
  5. 5Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk factors2024 · 1 citations