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March 17, 2026The Brazilian Journal of Infectious Diseases1 citationsOpen Access

Relapse of Sporotrichosis Leading to Fungal Arthritis of the Knee After Mucocutaneous Treatment

Relapse of Sporotrichosis Presenting as Insidious Fungal Arthritis of the Knee After Treated Mucocutaneous Disease: A Case Report With a Protracted Course and Unsatisfactory Therapeutic Response

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Authors

GCGuilherme Otávio Varino CornelioAMAlexandre Braga de MirandaMAMichelle Starling Alves de Araújo

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Overview

Case report reveals osteoarticular sporotrichosis recurrence in an immunocompetent individual, highlighting treatment challenges.

Key Points

  • To present a rare case of osteoarticular sporotrichosis that recurred after prior treatment of mucocutaneous disease.
  • Documented case of a 58-year-old woman with type 2 diabetes and chronic kidney disease.
  • Initial treatment with itraconazole for mucocutaneous sporotrichosis for 8 months.
  • Intraoperative diagnosis during knee arthroplasty revealed fungal infection.
  • Subsequent antifungal therapy included itraconazole and liposomal amphotericin B with adjusted regimens.
  • Confirmed diagnosis of osteoarticular sporotrichosis through cultures.
  • Persistent infection and significant pain despite more than one year of antifungal treatment.
  • Partial clinical response leading to functional limitations and ongoing surveillance needed.

Cite This Study

Cornelio et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef6ddeb47d591b8c58b9https://doi.org/10.1016/j.bjid.2026.105076
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