Functionalization of 4-Iodophenyl-O,O-diethylphosphonate via the Sonogashira Cross-Coupling Reaction as a Route to New Primary Phosphines and 1,5-Diaza-3,7-diphosphacyclooctanes

The synthesis of 4-(2′-phenylethyn-1′-yl)-O,O-diethylphosphonate, 4-(2′-phenylethyn-1′-yl)phosphine, and the corresponding 1,5-diaza-3,7-diphosphacyclooctane was presented. The reaction products were characterized by NMR spectroscopy. The conducted studies showed that 4-iodophenylphosphonate is a convenient reagent that undergoes functionalization via C–C cross-coupling reactions, enabling the synthesis of a wide range of functionalized phosphonates, phosphines, and their derivatives.