Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients

Muhammad .; Sadiq Azam; Noor Rehman; Alaa S. Alhegaili; Ibrar Khan; Fazal U Samad; Arfan Ahmad; Sajid Ali

doi:10.2174/0113816128426430251208153115

March 13, 2026Current Pharmaceutical Design

Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients

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Key Points

To investigate the genetic mutations in efflux pump genes of Salmonella typhi and their role in antibiotic resistance.
Analyzed clinical isolates of Salmonella typhi from typhoid patients.
Examined mutations in mdtABC efflux pump genes.
Evaluated the relationship between mutations and antibiotic resistance.
Observed a significant increase in multidrug resistance among the isolates.
Identified key mutations that likely enhance efflux pump function.
Correlated specific genetic variations with levels of antibiotic resistance.

Implication

Identifies genetic mutations in Salmonella typhi, highlighting implications for antibiotic resistance.

Abstract

This study highlights the alarming rise of multidrug resistance in S. typhi isolates and identifies key genetic mutations that may influence efflux pump function, potentially contributing to enhanced antibiotic resistance.

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Cite This Study

. et al. (2026) studied this question.

synapsesocial.com/papers/69b8f0f0deb47d591b8c5a8a https://doi.org/10.2174/0113816128426430251208153115

View Full Paper

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Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

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