Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients

Key Points

• To investigate the genetic mutations in efflux pump genes of Salmonella typhi and their role in antibiotic resistance.
• Analyzed clinical isolates of Salmonella typhi from typhoid patients.
• Examined mutations in mdtABC efflux pump genes.
• Evaluated the relationship between mutations and antibiotic resistance.
• Observed a significant increase in multidrug resistance among the isolates.
• Identified key mutations that likely enhance efflux pump function.
• Correlated specific genetic variations with levels of antibiotic resistance.