Identify phytoconstituents with inhibitory effects against NDM-1, a key factor in antibiotic resistance.
In silico screening of potential inhibitor compounds
In vitro testing of selected phytoconstituents against NDM-1 producing E. coli
Analysis of inhibitory activity
Bis-desmethoxycurcumin shows significant inhibitory activity against NDM-1
Supports the potential use of bis-desmethoxycurcumin in treating antibiotic-resistant infections
Abstract
Bis-desmethoxycurcumin from C. longa exhibits promising inhibitory activity against NDM-1-producing E. coli, supporting its potential use in adjuvant therapy to combat antibiotic resistance.