Cohort study shows dietary one-carbon nutrients lower PD risk in varied genetic risk groups, suggesting dietary importance.
Key Points
This study aims to examine the relationship between dietary one-carbon metabolism nutrients and the risk of Parkinson's disease, considering genetic factors.
Analyzed dietary intake of one-carbon metabolism nutrients via 24-hour recalls in a UK Biobank cohort.
Assessed Parkinson's disease incidence using validated ICD-10 codes.
Calculated genetic risk using polygenic risk scores.
Employed Cox proportional hazards models for association evaluations.
Conducted sensitivity analyses for robust findings.
Over 12 years, 1037 new cases of Parkinson's disease were identified among participants.
Higher intake of methionine, vitamin B6, folate, and vitamin B12 correlated with a reduced risk of developing Parkinson's disease.
Folate intake associated inversely with PD risk in low-risk genetic groups, while vitamin B12 linked to lower risk in high-risk groups.
Vitamin B6 showed a protective association against PD across both low and high genetic risk groups.