What question did this study set out to answer?

To investigate the effects of a ketogenic diet-derived faecal microbiota transplantation on sensorimotor gating deficits in a mouse model of schizophrenia.

March 18, 2026Food & Function0 citationsOpen Access

Ketogenic diet derived faecal microbiota transplantation improved sensorimotor gating deficit in an acute NMDA-receptor antagonist model of schizophrenia in mice

AKAnn-Katrin KraeuterAustralian Institute of Tropical Health and Medicine ZSZoltan SarnyaiAustralian Institute of Tropical Health and Medicine

Key Points

To investigate the effects of a ketogenic diet-derived faecal microbiota transplantation on sensorimotor gating deficits in a mouse model of schizophrenia.
Utilized an acute NMDA-receptor antagonist model to induce schizophrenia-like symptoms in mice.
Administered ketogenic diet and performed faecal microbiota transplantation.
Assessed sensorimotor gating using pre-pulse inhibition tests.
Mice receiving the ketogenic diet and transplant showed improved sensorimotor gating.
Demonstrated a significant reduction in deficits compared to control groups.

Abstract

Ketogenic diet (KD) shows promise as a novel treatment for schizophrenia, although its mechanisms of action are still unclear. KD has been shown to modify the gut microbiota and may...

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