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March 18, 2026PLOS Global Public HealthOpen Access

Decade-long antiretroviral therapy in Uganda: Population-health outcomes from a national HIV treatment cohort, 2014–2024

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Authors

MNMaria Magdalene NamagandaSGStathis GennatasLMLaura Merson

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Overview

Longitudinal analysis shows improved outcomes in PLWH in Uganda, indicating targeted interventions are needed.

Key Points

  • This analysis aims to understand the evolving profiles and outcomes of people living with HIV in Uganda over a decade.
  • Conducted a secondary analysis of data from a national HIV treatment cohort between 2014 and 2024.
  • Utilized descriptive statistics to summarize demographic and clinical characteristics at baseline and follow-up.
  • Analyzed data from 54,348 people living with HIV at 11 clinics of the AIDS Support Organisation (TASO).
  • 60.4% of people living with HIV were female, with a median age of 39 years.
  • By 2024, over 99% of antiretroviral therapy initiations were dolutegravir-based.
  • 12% of patients still presented with CD4 levels below 200 cells/µL despite overall immune recovery.
  • Common comorbidities included tuberculosis, hypertension, and diabetes, while socioeconomic vulnerabilities were prevalent.

Cite This Study

Namaganda et al. (2026) studied this question.

synapsesocial.com/papers/69ba426d4e9516ffd37a29f1https://doi.org/10.1371/journal.pgph.0005906
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Durable viral suppression in the dolutegravir era: a data-enabled, risk-stratified model for integrated HIV care in Uganda2026 · 2 citations
  2. 2Ten-year outcomes of antiretroviral therapy: a retrospective cohort study in Tshwane district, South Africa2025 · 1 citations
  3. 3Brief Report: Antiretroviral Treatment Use Over Time Among Adolescents and Young Adults in the Rakai Community Cohort Study, 2011–20202024
  4. 4Progress of HIV care cascade and transition dynamics along the continuum of care among persons living with HIV in Ifakara, Tanzania: a prospective study2026
  5. 5Shifting neuropsychiatric diagnoses across the antiretroviral therapy era at an urban Ugandan HIV centre: a descriptive analysis of routinely collected electronic health records, 2017 to April 20262026