ABSTRACT Infected wounds present a formidable challenge to healing due to their complex pathological microenvironment, whereas conventional dressings are often functionally limited and ill‐suited to adapt to dynamic wound changes. In this study, based on allantoin‐loaded ZIF8 nanoparticles (Alla@ZIF8) and methacrylated quaternary ammonium carboxymethyl chitosan/resveratrol composite hydrogels (RMQCC), we designed and developed an adaptive multifunctional hydrogel system (Alla@ZIF8‐Gel). This nanocomposite hydrogel exhibited multiple intelligent features, including pH‐responsiveness and morphological adaptability. The quaternary ammonium carboxymethyl chitosan imparted well biocompatibility and robust antimicrobial properties. Electrostatic interactions and hydrogen bonds endowed hydrogels with excellent injectability and self‐healing capabilities. The ZIF8 nanoparticles enabled the intelligent, on‐demand release of allantoin, thereby promoting tissue regeneration. Resveratrol conferred potent antioxidant, anti‐inflammatory, and immunomodulatory effects. The Alla@ZIF8‐Gel dynamically modulated drug release kinetics in response to the wound microenvironment, synergistically delivering antibacterial, antioxidant, anti‐inflammatory, and tissue‐regenerative functions. Both in vitro and in vivo experimental results demonstrated that this adaptive hydrogel markedly accelerated the healing of MRSA‐infected wounds, suppressed bacterial proliferation, alleviated oxidative damage and inflammatory responses, and enhanced collagen deposition, re‐epithelialization, and neovascularization. This work provides a novel design paradigm for the development of intelligent, multifunctional therapeutic materials for infected wound management, with significant translational potential for clinical application.
Zhu et al. (Mon,) studied this question.