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March 18, 2026Lara D. Veeken

B-cell monitoring predicts infection risk in childhood systemic lupus erythematosus patients on belimumab

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Authors

JGJun GuoYYYanjun YangLGLanlan Ge

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Overview

Nomogram predicts infection risk in childhood systemic lupus erythematosus patients on belimumab, suggesting benefits for personalized monitoring.

Key Points

  • The research aims to identify predictors of infection risk in childhood systemic lupus erythematosus patients undergoing treatment with belimumab.
  • Analyzed the effects of belimumab on B cell depletion and immunoglobulin G levels.
  • Developed a nomogram for risk stratification based on early B cell and IgG changes.
  • Profound B cell depletion is associated with a higher infection risk.
  • Significant reduction in IgG levels correlates with increased susceptibility to infections.
  • The nomogram serves as a practical tool for monitoring and risk assessment.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69ba42ae4e9516ffd37a3360https://doi.org/10.1093/rheumatology/keag116
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