Literature review highlights systemic involvement in bullous systemic lupus erythematosus, indicating significant treatment needs.
This study and literature review highlight that, although BSLE is an uncommon cutaneous manifestation of SLE, it is strongly associated with systemic involvement, particularly renal and hematologic disease, which often necessitates treatment with immunosuppressive agents.
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Rujitharanawong et al. (2026) studied this question.
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