Microneedle-Assisted CuNWs-MXene Heterostructure Enables Visualized Sub-Femtomolar Detection of Cervical Cancer miRNA

Key Points

• The research aims to develop a sensitive biosensor for detecting low-abundance cervix cancer microRNAs in tissue samples.
• Developed a microneedle-assisted biosensor utilizing CuNWs-MXene heterostructures.
• Tested the biosensor accuracy on formalin-fixed paraffin-embedded tissues.
• Analyzed the detection limits of miRNA quantification.
• Achieved sub-femtomolar detection sensitivity for cervical cancer miRNA.
• Outperformed traditional methods in quantifying low-abundance microRNAs.
• Demonstrated feasibility for clinical applications in cervical cancer management.