Comparative Efficacy of Elinzanetant Versus Other Non‐Hormonal Pharmaceutical Therapies for the Treatment of Moderate‐to‐Severe Vasomotor Symptoms Associated With Menopause: A Network Meta‐Analysis

Piotr Wojciechowski; Klaudia Kolonko; Andromachi Giannopoulou; Beata Smela; Elżbieta Olewińska; K.R. Bolling; Jenifer Sassarini; L.P. Shulman; Vikram Talaulikar

doi:10.1111/1471-0528.70213

March 15, 2026BJOG An International Journal of Obstetrics & GynaecologyOpen Access

Comparative Efficacy of Elinzanetant Versus Other Non‐Hormonal Pharmaceutical Therapies for the Treatment of Moderate‐to‐Severe Vasomotor Symptoms Associated With Menopause: A Network Meta‐Analysis

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Key Points

This analysis aims to compare the efficacy of elinzanetant with other non-hormonal therapies for managing vasomotor symptoms during menopause.
Conducted a network meta-analysis to evaluate various non-hormonal therapies.
Included indirect comparisons of elinzanetant with other treatments.
Assessed frequency and severity of vasomotor symptoms and improvements in sleep disturbances.
Elinzanetant demonstrated superior or comparable efficacy to non-hormonal therapies.
Significant reduction in the frequency of vasomotor symptoms was observed.
Improvement in sleep disturbances was noted with elinzanetant compared to alternatives.

Implication

Network meta-analysis shows elinzanetant reduces vasomotor symptoms in menopausal individuals, suggesting a strong therapeutic option.

Abstract

In this indirect comparison, elinzanetant showed superior or comparable efficacy to NKT or nHT in reducing the frequency and severity of VMS, along with improving sleep disturbances, supporting its role in VMS management.

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Cite This Study

Wojciechowski et al. (2026) studied this question.

synapsesocial.com/papers/69ba43b64e9516ffd37a5426 https://doi.org/10.1111/1471-0528.70213

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Comparative Efficacy of Elinzanetant Versus Other Non‐Hormonal Pharmaceutical Therapies for the Treatment of Moderate‐to‐Severe Vasomotor Symptoms Associated With Menopause: A Network Meta‐Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Comparative Efficacy of Elinzanetant Versus Other Non‐Hormonal Pharmaceutical Therapies for the Treatment of Moderate‐to‐Severe Vasomotor Symptoms Associated With Menopause: A Network Meta‐Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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