Serum Amyloid β Oligomer May Predict Treatment Response in Middle‐Aged and Late‐Life Patients With Depression

Key Points

• This research aims to determine if serum Aβ oligomers can predict treatment response in patients with depression.
• Analyzed serum Aβ oligomer levels in middle-aged and late-life patients with depression.
• Evaluated treatment responses to antidepressants in relation to Aβ oligomer levels.
• Assessed potential pathophysiological links to Alzheimer’s disease (AD) features.
• Higher serum Aβ oligomer levels correlate with a poor response to antidepressant treatment.
• Patients with low treatment response may exhibit similar features to those found in Alzheimer’s disease.
• Elderly patients may have increased neural vulnerability indicated by Aβ oligomer levels.