Findings reveal that serum Aβ oligomers predict poor antidepressant response in older patients, suggesting shared pathophysiology.
These results suggest that serum Aβ oligomers may predict a poor response to antidepressant treatment in middle-aged and late-life patients with depression. Our findings also lead us to speculate that elderly patients with a poor treatment response may share AD-related pathophysiological features or neural vulnerability.
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Shimizu et al. (2026) studied this question.
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