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The research aims to determine the protective effects of boric acid against cadmium-induced liver damage.

March 18, 20260 citationsOpen Access

Sıçan karaciğerinde akut kadmiyum kaynaklı oksidatif stres, inflamasyon, histopatolojik hasar ve proapoptotik değişiklikler üzerine borik asidin iyileştirici etkisi

FAFaik Veysel AkpulatDicle University MAMurat AkkuşDicle University EYEda YıldızhanRecep Tayyip Erdoğan University

Key Points

The research aims to determine the protective effects of boric acid against cadmium-induced liver damage.
Random assignment of 28 male Wistar albino rats into four groups: Control, Cd, BA, and Cd+BA.
Cd administered as a single oral dose (15 mg/kg) and BA given intraperitoneally (200 mg/kg) for 7 days.
Assessment of oxidative stress using serum malondialdehyde (MDA) and total oxidant status (TOS).
Histopathological evaluation of liver tissues for damage scoring.
MDA and TOS levels were highest in the Cd group and reduced in the Cd+BA group.
AST levels were significantly higher in the Cd group compared to the Cd+BA group.
LDH levels were also significantly lower in the Cd+BA group.
Histopathological examination revealed greater liver damage in the Cd group, with less inflammation and apoptosis in the Cd+BA group.

Abstract

Purpose: This study aims to investigate the ameliorative effects of boric acid (BA) on cadmium (Cd)-induced hepatotoxicity were investigated in rats. Materials and Methods: Twenty-eight male Wistar albino rats were randomly assigned to four groups (n=7 each): Control; Cd (single oral dose of Cd 15 mg/kg by gavage, no further treatment for 7 days); BA (boric acid 200 mg/kg/day intraperitoneally for 7 days); and Cd+BA (combined cadmium and boric acid). Serum malondialdehyde (MDA) and total oxidant status (TOS) were measured to assess oxidative stress. Results: MDA and TOS levels were highest in the Cd group compared with the other groups, while these levels were reduced in the Cd+BA group. AST levels were significantly elevated in the Cd group (194.42 U/L) compared with the Cd+BA group (110.57 U/L). Similarly, LDH levels were significantly lower in the Cd+BA group. Histopathological evaluation of liver tissues showed markedly higher damage scores in the Cd group, whereas inflammatory and proapoptotic changes were less pronounced in the Cd+BA group. Conclusion: These findings suggest that BA administration after acute Cd exposure may reduce hepatic injury by lowering oxidative stress, inflammation, and apoptosis.

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