Laboratory findings demonstrate robust anti-tumor activity of OSM CAR-T therapy in osteosarcoma, suggesting new treatment options.
Human ligand-based OSM CAR-T cells displayed anti-tumor effects against multiple osteosarcoma cell lines and patient samples. These effects were demonstrated in vitro, in xenograft models, and against a model simulating metastatic disease. Overall, this data supports the continued study of OSM-CAR-T cells as a new therapeutic avenue for osteosarcoma.
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Feinberg et al. (2026) studied this question.
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