Mixed Neuroendocrine-Nonneuroendocrine Neoplasms of the Pancreas: Unraveling the Concept and Applying It to Clinical Practice

The MiNEN concept, along with the evolving concept of mixed neoplasms with amphicrine features, can be helpful to describe groups of pancreatic neoplasms that exhibit evidence of differentiation along both neuroendocrine and nonneuroendocrine lineages. For individual neoplasms, however, the diagnosis should indicate the specific components represented to ensure appropriate clinical management.