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March 19, 2026Journal of Atherosclerosis and Thrombosis2 citationsOpen Access

A Single-Cell Analysis Reveals Macrophage Heterogeneity Driving Plaque Vulnerability in Coronary and Carotid Arteries

TYTakeshi YoshidaTETakuo EmotoHYHiroyuki Yamamoto

Key Points

  • This research aims to understand the differences in macrophage behavior in coronary and carotid arteries related to atherosclerosis.
  • Conducted single-cell analyses of macrophages from coronary and carotid arteries.
  • Examined morphological and histological differences in atherosclerosis.
  • Compared macrophage profiles in acute coronary syndrome and chronic coronary syndrome.
  • Identified distinct macrophage populations in coronary versus carotid arteries.
  • Found significant differences in plaque composition and vulnerability related to macrophage heterogeneity.

Abstract

Aim: Acute coronary syndrome (ACS) and ischemic stroke are major life-threatening conditions caused by atherosclerosis. Although the mechanisms of atherosclerosis appear to be broadly similar across different vascular beds, growing evidence suggests that there are morphological and histological differences between coronary and carotid atherosclerosis. To identify disease-specific therapeutic strategies, we aimed to compare ACS and chronic coronary syndrome (CCS) in coronary artery disease, and symptomatic and asymptomatic carotid artery disease.

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Cite This Study

Yoshida et al. (2026) studied this question.

synapsesocial.com/papers/69bb9212496e729e6297f5c7https://doi.org/10.5551/jat.65991
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