What question did this study set out to answer?

This study aims to examine the relationship between D-dimer and lymphocyte counts in the context of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB).

March 19, 2026Open Access

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D‐Dimer: A Mediator of the Association Between Lymphocyte and Dissemination of Pulmonary Tuberculosis: A Retrospective Cohort Study

YLYujun LinFujian Medical University DWDi WuFujian Medical University XCXiaohong ChenFujian Medical University

Key Points

This study aims to examine the relationship between D-dimer and lymphocyte counts in the context of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB).
Retrospective cohort study design
Analysis of D-dimer and lymphocyte counts in relation to PTB and EPTB
Identification of clinical thresholds for early intervention
D-dimer is an independent risk factor for PTB and EPTB
Lymphocyte counts show a protective effect against TB dissemination
D-dimer mediates 36.473% of the effect of lymphocyte counts on TB dissemination

Abstract

D-dimer is an independent risk factor and lymphocyte counts a protective factor for PTB + EPTB, with D-dimer mediating 36.473% of the lymphocyte effect. Clinically actionable thresholds (D-dimer > 0.170 mg/L and lymphocytes < 750 cells/μL) provide concrete targets for early intervention to prevent TB dissemination and improve outcomes.

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D‐Dimer: A Mediator of the Association Between Lymphocyte and Dissemination of Pulmonary Tuberculosis: A Retrospective Cohort Study

Key Points

Abstract

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