Background/Objectives: Sweeteners and sweetness enhancers (S BMI ≥ 25.0 kg/m2) were recruited from the one-year randomized controlled SWEET trial. Subjective appetite sensations were measured using visual analogue scales while fasting and nine times during a 250-min postprandial period. During this period, a standardized breakfast (0–10 min) was served and, 2 h later, a test drink containing either Ace-K/Cyc or water (120–130 min) was given. After 265 min, an ad libitum test meal was served. Results: Of 26 participants enrolled, 22 completed test day 2 and 16 completed test day 3. The S&SEs group rated lower prospective consumption and desire to eat something sweet after the test drink with Ace-K/Cyc compared to the sugar group consuming water (p 0.05). Conclusions: Ace-K/Cyc compared to water reduced feelings of prospective consumption and desire to eat something sweet acutely, after two months of weight loss, and after four months of weight loss maintenance. Due to the low sample size and power, larger studies are warranted to confirm these results.
Andersen et al. (Tue,) studied this question.