Research shows type 2 inflammation affects tissue remodeling in chronic rhinosinusitis with nasal polyps, suggesting new treatment targets.
This work establishes the type 2 inflammation-ALOX15-15(S)-HETE-PPAR-γ axis as a key driver of impaired tissue remodeling in ECRSwNP through TGF-β1 suppression. These findings provide novel mechanistic insights into the inflammation-metabolism-remodeling interplay in CRSwNP and highlight promising therapeutic targets for this refractory condition.
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Li et al. (2026) studied this question.
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