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March 19, 2026Journal of Crohn s and Colitis

Distinct hepcidin patterns in Crohn’s disease and ulcerative colitis: links to iron homeostasis and inflammatory activity

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Authors

FMF MagroPMP MinistroHSHelena Tavares de Sousa

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Overview

Cross-sectional analysis reveals hepcidin's relationship to iron levels and inflammation in IBD, indicating its potential as a biomarker.

Key Points

  • This study aims to understand how hepcidin regulates iron metabolism in Crohn's disease and ulcerative colitis and its links to inflammation.
  • Cross-sectional multicenter study with 589 individuals, including controls and patients with UC or CD.
  • Patients were categorized based on iron status and disease activity.
  • Blood samples measured serum hepcidin, iron levels, and inflammatory markers.
  • Statistical analyses included group comparisons and multivariable linear regressions.
  • Hepcidin levels were higher in CD patients compared to controls under similar iron status categories.
  • Positive correlation found between hepcidin and C-reactive protein in CD, while UC showed a negative correlation with fecal calprotectin.
  • Ferritin exhibited the strongest association with hepcidin levels across all groups.

Cite This Study

Magro et al. (2026) studied this question.

synapsesocial.com/papers/69bb926a496e729e6297fbf3https://doi.org/10.1093/ecco-jcc/jjag023
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