Serum periostin levels were significantly higher in adults with Osteogenesis Imperfecta than controls (796.5 vs 713.6 pmol/L, p=0.017) and independently associated with severe fractures.
Are serum periostin levels elevated in adults with Osteogenesis Imperfecta and associated with disease severity?
Elevated circulating periostin levels are associated with Osteogenesis Imperfecta and its disease severity, suggesting its potential as a biomarker.
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Abstract Objective In Osteogenesis Imperfecta (OI), phenotypic variability and the limited predictive value of genotype-phenotype correlations underscore the need for reliable predictive marker of disease severity. Periostin is a matricellular protein involved in bone formation, remodeling, and response to mechanical stress. It interacts with type I collagen and modulates osteoblast activity via Wnt/β-catenin and TGF-β signaling. Given its established role in other bone disorders, we hypothesized that circulating periostin may be a relevant biomarker in OI. Methods We performed a matched case–control analysis of serum periostin levels in 61 adult patients with OI and 61 age-, sex-, and BMI-matched controls. Periostin was measured by ELISA. Associations between periostin levels and clinical variables were assessed using t-tests, Pearson correlations, and multivariable linear regression models. Results Mean periostin levels were significantly higher in OI patients than in controls (796.5 ± 209 vs. 713.6 ± 167 pmol/L, p = 0.017). Among OI patients, higher periostin level was associated with female sex (p = 0.01), presence of scoliosis (p = 0.01), and Sillence type III (p = 0.05). Positive correlations were observed between periostin and markers of axial skeletal severity as height–wingspan discrepancy (r = 0.30, p = 0.023). In multivariable analysis, the number of severe fractures (defined as femur/pelvis/humerus/vertebral fractures) was independently associated with higher periostin level (β = 25.6, p = 0.041), while smoking was negatively associated (β = –269.8, p = 0.012). Conclusion This study is the first to report the elevated circulating level of periostin in adults with OI and its association with disease severity.
Mercier-Guery et al. (Sat,) reported a other. Serum periostin levels were significantly higher in adults with Osteogenesis Imperfecta than controls (796.5 vs 713.6 pmol/L, p=0.017) and independently associated with severe fractures.
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