Pd-catalyzed enantio-and diastereoselective synthesis of N-N atropisomeric indoles via N-alkylation reaction

X. LU; Yongqiang Xu; Wenkai Li; Yuhan Zhou; Jingping Qu; Baomin Wang

doi:10.1039/d6cc00641h

January 1, 2026Chemical Communications

Pd-catalyzed enantio-and diastereoselective synthesis of N-N atropisomeric indoles via N-alkylation reaction

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Key Points

This research aims to establish an effective method for synthesizing N-N axially chiral indoles using Pd-catalyzed N-alkylation.
Pd-catalyzed N-alkylation reaction
Focus on substrate tolerance and yield
Assessment of enantio- and diastereoselectivity
Achieved high enantioselectivity
Demonstrated good substrate tolerance
Reported significant diastereoselectivity in product formation

Implication

A method demonstrates high enantio- and diastereoselectivity in synthesizing chiral indoles, suggesting broad application potential.

Abstract

We disclose a method for the asymmetric synthesis of N-N axially chiral indole compounds by Pd-catalyzed N-alkylation reaction, featuring good substrate tolerance and yield with high enantio-and diastereoselectivity. Furthermore, the...

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Cite This Study

LU et al. (2026) studied this question.

synapsesocial.com/papers/69bb92ae496e729e629803b3 https://doi.org/10.1039/d6cc00641h

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Pd-catalyzed enantio-and diastereoselective synthesis of N-N atropisomeric indoles via N-alkylation reaction

Key Points

Implication

Abstract

Discussion

Cite This Study

Pd-catalyzed enantio-and diastereoselective synthesis of N-N atropisomeric indoles via N-alkylation reaction

Key Points

Implication

Abstract

Discussion

Cite This Study

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