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March 19, 2026The Korean journal of painOpen Access

Manipulation therapy alleviates neuropathic pain via the SOCS1 m 6 A epigenetic loop

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Authors

LWLiang WuXWXiunan WangPYPeng Yang

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Overview

Demonstrates manipulation therapy alleviates neuropathic pain, suggesting a new therapeutic approach.

Key Points

  • The research aims to explore how manipulation therapy affects neuropathic pain through an epigenetic mechanism.
  • Conducted experiments to evaluate the effects of manipulation therapy on neuropathic pain.
  • Measured inflammation and RNA m6A methylation changes in the spinal cord.
  • Utilized the SOCS1/TLR4 pathway as a focal point of investigation.
  • Manipulation therapy significantly reduced levels of neuropathic pain.
  • It altered inflammation markers in the spinal cord.
  • m6A methylation was modified, linking epigenetic changes to pain relief.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69bb92d1496e729e62980779https://doi.org/10.3344/kjp.25124
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