Cu-Guanidine-Catalysed Asymmetric Protoboration of Internal 1,3-Dienes for One-Pot Access to Chiral Homoallylic Alcohols

Key Points

• To develop an efficient method for the enantioselective protoboration of internal 1,3-dienes using a copper-guanidine catalyst.
• Utilized a copper-guanidine catalyst for protoboration
• Conducted reactions under mild conditions
• Facilitated one-pot reaction with aldehydes to obtain products
• Successfully achieved enantioselective protoboration
• Produced α-stereogenic Z-allyl boronates
• Enabled one-pot crotylboration with aldehydes, yielding chiral alcohols