Cobalt-Catalyzed Synergistic Oxidation of Benzylic C–H Bonds Using Ozone and Hydrogen Peroxide

Shiyun Li; Wenzhi Cui; Lulu Wang; Jun Huang; Bin Wen; Xingquan Chen; Haibo Zhu; Xiaojun Bao

doi:10.1039/d6ob00130k

January 1, 2025Organic & Biomolecular Chemistry

Cobalt-Catalyzed Synergistic Oxidation of Benzylic C–H Bonds Using Ozone and Hydrogen Peroxide

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Key Points

The aim is to efficiently transform benzylic C(sp³)–H bonds into carbonyl groups using a mild catalytic approach.
Utilized cobalt as a catalyst for oxidation reactions
Applied ozone and hydrogen peroxide as oxidizing agents
Conducted reactions under mild conditions to favor product formation
Successfully converted benzylic C–H bonds into various carbonyl functionalities
Enhanced synthesis of aromatic carboxylic acids and ketones
Demonstrated effectiveness of the method in producing high-value compounds

Implication

Demonstrates the oxidation of benzylic C–H bonds, suggesting a new method for aromatic compound synthesis.

Abstract

Oxidative transformation of benzylic C(sp³)–H bonds into carbonyl functionalities under mild conditions offers an efficient and versatile strategy for synthesizing high-value aromatic carboxylic acids and ketones. Herein, we report a...

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69bb9300496e729e62980c4f https://doi.org/10.1039/d6ob00130k

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Cobalt-Catalyzed Synergistic Oxidation of Benzylic C–H Bonds Using Ozone and Hydrogen Peroxide

Key Points

Implication

Abstract

Discussion

Cite This Study

Cobalt-Catalyzed Synergistic Oxidation of Benzylic C–H Bonds Using Ozone and Hydrogen Peroxide

Key Points

Implication

Abstract

Discussion

Cite This Study

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