Clinical Characteristics, Prognostic Factors, and Outcomes of Patients With Medullary Thyroid Carcinoma: A Retrospective Review From a Tertiary Care Hospital
Retrospective review assesses survival predictors in medullary thyroid carcinoma patients, indicating early intervention improves outcomes.
Key Points
This research aims to analyze the clinical characteristics and prognostic factors affecting outcomes in patients with medullary thyroid carcinoma (MTC).
Conducted a retrospective observational study of patients with histologically confirmed MTC from December 2008 to December 2019.
Collected data on demographics, tumor characteristics, MEN2 status, biochemical markers, and treatment modalities.
Evaluated postoperative serum calcitonin and CEA levels and calcitonin doubling time as prognostic indicators.
Performed statistical analyses using SPSS version 26.0.
Total of 90 patients with MTC included, mean age 39.3 years, 43.3% male.
37.8% had cervical lymph node involvement, and 13.3% had distant metastases.
Disease-free status showed significant correlation with improved overall survival (p < 0.001).
Elevated postoperative calcitonin and CEA levels linked to poorer survival outcomes.
Distant metastases, especially bone involvement, resulted in significantly worse outcomes (p < 0.001).